Isolated limb perfusion for in-transit melanoma metastases: Melphalan or TNF-melphalan perfusion?
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منابع مشابه
Isolated limb perfusion with melphalan for melanoma.
Isolated limb perfusion with melphalan is a well-established and effective treatment for inoperable melanoma metastases of the extremities, with an overall response rate of 80% and a complete response rate of 54%. The surgical technique is complex and serious morbidity can occur, but with attention to detail major side effects can be kept to a minimum. This article reviews the technique, result...
متن کاملSystemic toxicity after isolated limb perfusion with melphalan for melanoma.
Systemic exposure to melphalan is minimized during isolated limb perfusion (ILP) by isolating a limb from the rest of the body. Consequently, there should be no toxicity to vital organs. At present systemic toxicity after ILP has not been studied in detail. Therefore, the incidence, nature and risk factors of systemic toxicity was retrospectively studied in 368 patients who underwent a single I...
متن کاملReview of regional limb perfusion with melphalan for malignant melanoma.
Children's Tumours-Steward MRDIC"JoAL also to direct their investigations towards problems of the disease as it affects children. Conclusion It is realized that centralization makes visiting of children in hospital and outpatient attendance somewhat difficult, and for this reason a case can be made for treating children with leukaemia near their homes. But the initial treatment of those with no...
متن کاملIsolated Limb Perfusion with Melphalan and TNF-α in the Treatment of Extremity Sarcoma
Isolated limb perfusion (ILP) with chemotherapy alone has uniformly failed in the treatment of irresectable extremity soft tissue sarcomas. The addition of tumor necrosis factor-alpha (TNF-alpha) to this treatment approach contributed to a major step forward in the treatment of locally advanced extremity soft tissue sarcoma (STS). High response rates and limb salvage rates have been reported in...
متن کاملOne hundred consecutive isolated limb perfusions with TNF-alpha and melphalan in melanoma patients with multiple in-transit metastases.
OBJECTIVE The aim of this study is to describe the experience with 100 TNF-based ILP for locally advanced melanoma and to determine prognostic factors for response, time to local progression, and survival. METHODS One hundred TNF-based ILPs were performed between 1991 and 2003 in 87 patients for whom local control by surgery of in-transit melanoma metastases was impossible. In total, 62 iliac...
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ژورنال
عنوان ژورنال: Journal of Surgical Oncology
سال: 2014
ISSN: 0022-4790
DOI: 10.1002/jso.23552